1) to prepare (land) by ploughing etc; help (crops) to grow (e.g. by breaking up the soil around them) (cultivate)

2) the breaking up or ending (of a marriage, partnership, formal meeting etc) (dissolution)

3) (to use) a heavy frame with metal teeth or discs for breaking up (ground) after ploughing (harrow)

4) a selection; a heavy tool with an iron head having two pointed ends, used for breaking up hard surfaces; a small, sharp pointed instrument: a toothpick; to take up, remove, pull away, (something) with the fingers (pick)